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- bs-3907P
- 2025年10月16日
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500ug
| 产品编号 | bs-3907P |
| 英文名称 | Legumain Antibody Blocking Peptide |
| 中文名称 | 半胱氨酸蛋白酶封闭多肽 |
| 英文别名 | AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1; LGMN_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Hormone biosynthesis Cell Biology > Other Antibodies > Plant related targets Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases Immunology > Cell Type Markers > Non-CD > APC Metabolism > Pathways and Processes > Endocrine metabolism > Hormone biosynthesis Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone |
| 亚细胞定位 | Lysosome (By similarity). |
| 组织特异性 | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
| 翻译后修饰 | Glycosylated. |
| 相似性 | Belongs to the peptidase C13 family. |
| 功能 | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008]. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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