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- bs-14578P
- 2026年10月10日
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500ug
| 产品编号 | bs-14578P |
| 英文名称 | EME2 Antibody Blocking Peptide |
| 中文名称 | 减数分裂内切酶EME2封闭多肽 |
| 英文别名 | EME1, S. pombe, homolog of, 2; Eme2; EME2_HUMAN; essential meiotic endonuclease 1 homolog 2; essential meiotic endonuclease 1, S.pombe, homolog of, 2; essential meiotic structure-specific endonuclease subunit 2; gs125; homolog of yeast EME1 endonuclease 2; Probable crossover junction endonuclease EME2; SLX2 structure-specific endonuclease subunit homolog B; SLX2B. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with MUS81. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the EME1/MMS4 family. |
| 功能 | Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]Eme2 is a 379 amino acids nuclear protein. As a member of the Eme2/Mms4 family, Eme2 associates with MUS81 to constitute a DNA structure-specific endonuclease. The MUS81-Eme2 complex cleaves branched DNA structures, especially those arising during stalled DNA replication such as replication forks and 3' DNA flaps. Expressed as two alternatively spliced isoforms, Eme2 is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. Defects in the gene encoding WDR59 may be associated with the rare disorder Rubinstein-Taybi syndrome or Crohn's disease, which is a gastrointestinal inflammatory condition. |
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文献和实验相关实验
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, activate AEC buffer using H2 O2 (see Step 25). Anti-CD3 monoclonal antibody (mAb) (Fisher Scientific) Blocking buffer for ELISPOT assay CEF peptide pool (available from the NIH AIDS Research and Reagent Program and other commercial
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EME2 Ab Blocking Peptide(bs-14578P)-500ug
￥880
