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- Bioss
- bs-12027P
- 2026年10月10日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-12027P |
| 英文名称 | GPCR GPR126 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体126封闭多肽 |
| 英文别名 | APG1; Developmentally regulated G-protein-coupled receptor; dj287g14.2; DREG; G-protein coupled receptor 126; GP126_HUMAN; GPR126; HBV PreS1-transactivated protein 2; OTTHUMP00000017320; OTTHUMP00000237093; OTTHUMP00000237094; OTTHUMP00000237115; Probable G-protein coupled receptor 126 [Precursor]; Probable G-protein coupled receptor 126; PS1TP2; Vascular inducible G protein-coupled receptor; VIGR; GPCR GPR126. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane. Detected on the cell surface of activated but not resting umbilical vein. |
| 组织特异性 | Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. |
| 翻译后修饰 | Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. |
| 相似性 | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. _x000D_ Contains 1 CUB domain. _x000D_ Contains 1 GPS domain. _x000D_ Contains 1 pentaxin domain. |
| 功能 | Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR126 (G protein-coupled receptor 126), also known as APG1, DREG, VIGR or PS1TP2, is a 1,221 amino acid multi-pass membrane protein that contains one pentaxin domain, one GPS domain and one CUB domain. Existing as three alternatively spliced isoforms, GPR126 functions as an orphan G protein-coupled receptor that, when subject to genetic variation, may influence stature and adult height. |
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ADGRG6 | GPR126 Ab Blocking Peptide(bs-12027P)-500ug
￥880
