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- bs-22363P
- 2025年10月16日
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500ug
| 产品编号 | bs-22363P |
| 英文名称 | CDH5 Antibody Blocking Peptide |
| 中文名称 | 血管内皮钙粘蛋白封闭多肽 |
| 英文别名 | VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Cell adhesion > Cadherins Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell adhesion molecules Cardiovascular > Cardiovascular Markers > Cell Markers > Endothelial Cells Cardiovascular > Vasculature > Endothelium Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cadherins Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cell Adhesion Molecules > Endothelial Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cell Adhesion Molecules > Vascular |
| 亚基 | Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. |
| 亚细胞定位 | Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. |
| 组织特异性 | Endothelial tissues and brain. |
| 翻译后修饰 | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. |
| 相似性 | Contains 5 cadherin domains. |
| 功能 | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-0878P is one synthetic peptide derived from mouse Vascular endothelial cell cadherin. This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]. |
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文献和实验[IF={{ 5.3 }}] {Luo Peng. et al. Microvolumetric determination of thrombomodulin based on competitive immunoreaction using a portable glucometer. MICROCHIM ACTA. 2024 Oct;191(10):1-10} {} {}
or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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