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| 产品编号 | bs-12028P |
| 英文名称 | GPCR GPR105 Antibody Blocking Peptide |
| 中文名称 | G蛋白偶联受体105封闭多肽 |
| 英文别名 | A330108O13Rik; G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; G-protein coupled receptor 105; GPR105; KIAA0001; P2RY14; P2Y purinoceptor 14; P2Y(14) receptor; P2Y14; P2Y14 receptor; P2Y14_HUMAN; Purinergic receptor P2Y G protein coupled 14; Similar to TYPE-1 Angiotensin II receptor; UDP-glucose receptor; GPCR GPR105. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | GPR105 is widely expressed throughout many brain regions where it localizes to glial cells, and specifically co-localizes with astrocytes. GPR105 is upregulated when a tissue is immunologically challenged with lipopolysaccharide, leading to the theory that GPR105 may play an important role in modulating peripheral and neuroimmune function. |
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文献和实验Nature！中美学者共同破译粘附类 GPCR 自激活机制之谜
作用，对 Stachel 序列介导的粘附类受体机制有了深入了解。同时为 Stachel 序列外源短肽设计提供了依据，为靶向粘附类受体相关疾病的鉴定和治疗奠定了基础。 图 3：GPR133-CTF–Gs 和 GPR114-CTF–Gs 复合物结构，来源 Nature 在 Tethered peptide activation mechanism of the adhesion GPCR ADGRG2 and ADGRG4 工作中，研究团队通过冷
同日 4 篇 Nature！中美学者共同破译粘附类 GPCR 自激活机制之谜
Gs 和 GPR114-CTF–Gs 复合物结构，来源 Nature 在 Tethered peptide activation mechanism of the adhesion GPCR ADGRG2 and ADGRG4 工作中，研究团队通过冷冻电镜技术解析了 Stachel 序列激活的 ADGRG2-β-Gs 和 ADGRG4-β-Gs 的复合物结构，揭示了 Stachel 序列与 aGPCR 的直接作用机制，发现 Stachel 序列 5 个疏水氨基酸呈手指状分布，在 Stachel
or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
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