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- 2025年10月16日
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| 产品编号 | bs-8624P |
| 英文名称 | NEU1/Neuraminidase Antibody Blocking Peptide |
| 中文名称 | 神经氨酸酶1封闭多肽 |
| 英文别名 | Acetylneuraminyl hydrolase; exo-alpha-sialidase; G9 sialidase; Lysosomal sialidase; N acetyl alpha neuraminidase 1; N-acetyl-alpha-neuraminidase 1; NANH; NEU; NEU1; NEUR1_HUMAN; Neuraminidase 1; Neuraminidase; SIAL1; sialidase 1 (lysosomal sialidase); Sialidase 1; Sialidase, lysosomal; Sialidase-1. |
| 纯化方法 | HPLC |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Amino acid metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Signal Transduction > Metabolism > Amino Acids Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Interacts with cathepsin A (protective protein),beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex. |
| 亚细胞定位 | Lysosome membrane. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. |
| 组织特异性 | Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. |
| 翻译后修饰 | N-glycosylated. Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. |
| 相似性 | Belongs to the glycosyl hydrolase 33 family. Contains 4 BNR repeats. |
| 功能 | Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. [provided by RefSeq, Jul 2008] |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Hematopoietic Stem Cell Targeting with Surface-Engineered Lentiviral Vectors
Transfection Kit (Clontech) CD34+ cell separation kit (CD34 MicroBead Kit containing anti-human CD34 MicroBeads and Blocking Reagent; Miltenyi Biotec) Cellgro medium (serum-free medium; Cellgenix) DMEM for HSC Fetal calf serum (FCS
Synthesis and Probing of Membrane-bound Peptide Arrays
can be made. For the introduction of randomized X positions in the peptide sequences, take the appropriate Fmoc-AA-mix stock solution from the freezer, bring to room temperature, and activate by adding DIC (1.5 µl per 100 µl-vial
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