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- bs-17202P
- 2025年10月16日
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500ug
| 产品编号 | bs-17202P |
| 英文名称 | TAOK3 Antibody Blocking Peptide |
| 中文名称 | JNK/ SAPK抑制激酶封闭多肽 |
| 英文别名 | CTCL tumor antigen HD CL 09; CTCL-associated antigen HD-CL-09; Cutaneous T cell lymphoma tumor antigen HD CL 09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell derived protein kinase; Dendritic cell-derived protein kinase; DKFZp666H245; DPK; FLJ31808; hKFC A; hKFC-A; JIK; JNK/SAPK inhibitory kinase; JNK/SAPK-inhibitory kinase; Jun kinase inhibitory kinase; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18; Serine kinase; Serine/threonine-protein kinase TAO3; STE20 like kinase; TAO kinase 3; TAOK3; TAOK3_HUMAN; Thousand and one amino acid protein 3. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚细胞定位 | Cytoplasm. Cell membrane. Also localized to the peripheral cell membrane. |
| 组织特异性 | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
| 翻译后修饰 | Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. |
| 功能 | Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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