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- Bioss
- bs-13503P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13503P |
| 英文名称 | GPBP1 Antibody Blocking Peptide |
| 中文名称 | 富含GC启动子结合蛋白1/血管壁相连蛋白封闭多肽 |
| 英文别名 | Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity). |
| 亚细胞定位 | Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm. |
| 组织特异性 | Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells. |
| 相似性 | Belongs to the vasculin family. |
| 功能 | Functions as a GC-rich promoter-specific transactivating transcription factor. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis. |
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GPBP1 Antibody Blocking Peptide(bs-13503P)-500ug
￥880
