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- bs-12214P
- 2025年10月16日
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500ug
| 产品编号 | bs-12214P |
| 英文名称 | ZNF195 Antibody Blocking Peptide |
| 中文名称 | 锌指蛋白195封闭多肽 |
| 英文别名 | Zinc finger protein 195; ZNFP104; ZN195_HUMAN . |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nuclear |
| 组织特异性 | Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney. |
| 相似性 | Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 1 KRAB domain. |
| 功能 | Zinc finger proteins are an important class of eukaryotic DNA binding proteins. The zinc finger motif contains spatially conserved cysteines and histidines, which bind a zinc ion. The most common zinc finger motif is the C2H2 type, which was first identified in the Drosophila segmentation gene, Kruppel. The human genome has several hundred Kruppel related zinc finger genes. About one third of these human Kruppel type genes also code for a highly conserved region, the Kruppel associated box (KRAB domain), comprising approximately 75 amino acids found at the N terminal end. The zinc finger gene ZNF195 contains an N terminal KRAB domain and 14 tandemly repeated Kruppel type zinc finger motifs at its C terminus. ZNF195 may be involved in transcriptional regulation. It is expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in foetal lung, kidney and brain. There is little expression in adult lung, liver and kidney. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 195 (ZNF195), also known as ZNFP104, is a 629 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF195 is expressed in adult brain, heart, placenta, pancreas and skeletal muscle and in fetal brain, lung and kidney. ZNF195 contains ten C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation. Three isoforms of ZNF195 exist as a result of alternative splicing events. |
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ZNF195 Antibody Blocking Peptide(bs-12214P)-500ug
￥880
