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- TD-HY13948
- 2026年01月26日
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88
- 规格：
20mg
| Product Name | Angiotensin II human (Synonyms: 血管紧张素Ⅱ; Angiotensin II; Ang II; DRVYIHPF) |
| Cat. No. | TD-HY13948 |
| Description | Angiotensin II 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human 在调节人类血压中起着核心作用，主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。Angiotensin II human 刺激交感神经刺激，增加醛固酮生物合成和肾脏活动。Angiotensin II human 诱导血管平滑肌细胞生长，增加成纤维细胞中 I 型和 III 型胶原的合成，导致血管壁和心肌增厚，并导致纤维化。Angiotensin II human 也诱导细胞凋亡 (apoptosis)。Angiotensin II human 通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。 |
| Purity | 99.98% |
| CAS No. | 4474-91-3 |
| 分子式 | C₅₀H₇₁N₁₃O₁₂ |
| 分子量 | 1046.18 |
| Sequence | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe |
| Sequence Shortening | DRVYIHPF |
| 作用靶点 | Angiotensin Receptor; Apoptosis |
| 作用通路 | GPCR/G Protein; Apoptosis |
| 储存方式 | Sealed storage, away from moisture and light, under nitrogen Powder：-80°C, 2 years；-20°C, 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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文献和实验Characterization of Angiotensin II Receptors
. Christ, D.D. 1995. Human plasma protein binding of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) and its pharmacologically active metabolite EXP3174. J. Clin. Pharmacol. 35:515‐520
Measurement of Renal Tubular Angiotensin II
, in part, by angiotensin II (Ang II), a peptide that is made up of eight amino acids. By activating Ang II receptors on both the basolateral and luminal membranes, Ang II serves a major function in determining how the kidney processes
Immunohistochemical Detection of Angiotensin II Receptor
This chapter deals with immunohistochemical detection of low copy molecules in tissue. We will focus on peptide receptors, but the same principles apply to hormones, autacoid substances, enzymes, and signaling molecules. Several approaches
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