- ￥1350 - 3000
- Proteintech
- 25277-1-AP
- 2025年10月13日
- WB, IHC, IF/ICC, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human ITGB4 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, IHC, IF/ICC, ELISA
- 靶点：
Integrin Beta 4
- 抗体英文名：
Integrin Beta 4 Polyclonal antibody
- 抗体名：
Integrin Beta 4 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | BxPC-3 cells, mouse pancreas tissue, rat skin tissue |
| Positive IHC detected in | human breast cancer tissue, human pancreas cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | A431 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
25277-1-AP targets Integrin Beta 4 in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, IHC, IF/ICC, ELISA |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 |
CatNo: Ag16460 Product name: Recombinant human ITGB4 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1411-1752 aa of BC126411 Sequence: VLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | integrin, beta 4 |
| 别名 | CD104, GP150, Integrin beta 4, integrin, beta 4, ITGB4 |
| 计算分子量 | 1752 aa, 195 kDa |
| 观测分子量 | 200 kDa |
| GenBank蛋白编号 | BC126411 |
| 基因名称 | Integrin beta 4 |
| Gene ID (NCBI) | 3691 |
| RRID | AB_2880002 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P16144 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Biochem Biophys Res Commun A mutation found in esophageal cancer alters integrin β4 mRNA splicing.Authors - Gabriel T Kelly |
| mouse | IF | J Oral Biosci Mirror-polished ceria-stabilized zirconia/alumina nanocomposite enhances gingival junctional epithelial cell adhesionAuthors - Shoma Yamamori |
14-3-3 sigma 14-3-3 sigma亚硫酸钠修饰的DNA 14-3-3 zeta c-Fos FosB Fra-1 Fra-2 c-Jun JunB JunD Fibronectin PAI-1 M16006 PAI-1 XM009352 GM-CSF FHIT IL-4 CD2AP real-time RT-PCR CCAAT/enhancer binding protein (C/EBP)：alpha / beta / delta
10X TBS：24.2 g Trisbase, 80 g NaCl；用1N HCl调pH为 7.6 7. 甲醇 8. TBS/T缓冲液：1X TBS, 0.1% Tween-20 9. 封闭缓冲液(TBS/T)：1X TBS,0.1% Tween-20加5% w/v脱脂奶粉或BSA 10. 一抗的稀释：1X TBS,0.1% Tween-20 加 5% BSA ( 多抗) 或 5%脱脂奶粉( 单抗)。Note： 一般来说，BSA被推荐用于多克隆抗体
[资源] 所有的看家基因(housekeeping genes)列表+引物设计服务
phosphatase 2 (formerly 2A), catalytic subunit, beta isoform (PPP2CB), mRNA 1195 NM_004910 Homo sapiens phosphatidylinositol transfer protein, membrane-associated (PITPNM), mRNA 869 NM_004517 Homo sapiens integrin-linked kinase (ILK), mRNA 654 NM
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