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- IHC0545H
- 2025年10月15日
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50T
| 产品编号 | IHC0545H |
| 英文名称 | Human Thymidylate synthase Ready-To-Use IHC Kit |
| 中文名称 | 人胸苷酸合成酶即用型免疫组化试剂盒 |
| 英文别名 | HST422; OK/SW-cl.29; TMS; TS; TYMS |
| 产品应用 | IHC-P Not yet tested in other applications. |
| 交叉反应 | Human |
| 亚基 | Homodimer. |
| 亚细胞定位 | #Cytoplasm #Membrane #Mitochondrion #Mitochondrion inner membrane #Nucleus |
| 功能 | Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway. |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 背景资料 | Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas. |
| 应用 | 推荐稀释比例 |
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0545H (Human Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0545H (Human Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Human lymph nodes tissue slide using IHC0545H (Human Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Human ovarian cancer tissue slide using IHC0545H (Human Thymidylate synthase Kit).
Immunohistochemical analysis of paraffin embedded Human gastric cancer tissue slide using IHC0545H (Human Thymidylate synthase Kit).
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Human Thymidylate synthase Ready-To-Use IHC Kit(IHC0545H)-50T
￥3200
