- ￥358 - 963
- Bioss
- D59424
- 2025年10月17日
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- 规格：
1mg/1mL x 10mM (in DMSO)
| 规格： | 1mg | 产品价格： | ￥358.0 |
|---|---|---|---|
| 规格： | 1mL x 10mM (in DMSO) | 产品价格： | ￥963.0 |
| 产品编号 | D59424 |
| 英文名称 | Avitinib |
| 中文名称 | 艾维替尼 |
| 英文别名 | AC0010 |
| 理论分子量 | 487.53 |
| 保存条件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR. |
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文献和实验Clonality - X Chromosome Inactivation Assay
can utilize X chromosome inactivation (methylation) to determine the clonality status of a tumor or premalignant lesion in females. The technique is based on a methylation-sensitive restriction enzyme and analysis of a polymorphic locus on the X chromosome
Northern Blot: Glyoxal/DMSO Adapted from Molecular Cloning (Maniatis), Current Protocols in Molecular Biology, and J. Yost Lab (UMN) Objective: Glyoxal/DMSO gels are great for determining sizes of RNA especially in conjunction
Analysis of Proteins using Small Format 2D Gel Electrophoresis
Analysis of 2D proteins profiles Images of the gels to be analysed are captured using a various methods. Many of the images presented on this site were captured as 1024 x 1024 pixel images using a video camera attached to a Gemini image analysis
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