- ￥1996 - 3379
- Bioss
- D55822
- 2025年10月17日
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1mg/2mg
| 规格： | 1mg | 产品价格： | ￥1996.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥3379.0 |
| 产品编号 | D55822 |
| 英文名称 | Syk Inhibitor II dihydrochloride |
| 英文别名 | Syk Inhibitor II (hydrochloride) |
| 理论分子量 | 413.22 |
| 保存条件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). |
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文献和实验Characterization of Angiotensin II Receptors
site. The K d for unlabeled Ang II is 3.934 nM, and the B max is 2.468 pmol/mg of protein. Data were analyzed using LIGAND. B, bound; F, free; T, unlabeled [Ang II] (M). View Image
Analysis of Proteins using Small Format 2D Gel Electrophoresis
twice with PBS-A and lysed in 0.2 ml of 2D lysis buffer (0.01M Tris-HCl, pH 7.4, 1mM EDTA, 8M urea, 0.05M dithiothreitol, 10% (v/v) glycerol, 5% (v/v) Nonidet P-40, 200µg/ml RNAse A, 6% (w/v) pH 3.5-10 carrier ampholytes ("Resolyte", Merck
V294.PART II，Chapter 3 划痕实验(Wound-Healing Assay)
contact-inhibited mammalian cell line. J. Cell Physiol. 66, 325–333. 2. Haudenschild, C. C. and Schwartz, S. M. (1979) Endothelial regeneration. II.Restitution of endothelial continuity. Lab Invest. 41, 407–418. 3. Han, D. C., Rodriguez, L. G
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