- ￥1364 - 3111
- Bioss
- D53926
- 2025年10月17日
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1mg/5mg
| 规格： | 1mg | 产品价格： | ￥1364.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥3111.0 |
| 产品编号 | D53926 |
| 英文名称 | EP4 receptor antagonist 1 |
| 理论分子量 | 458.43 |
| 保存条件 | Powder: -20℃ for 3 years | In solvent: -80℃ for 1 year |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EP4 receptor antagonist 1 is an effective and selective antagonist of prostanoid EP4 receptor with IC50s of 6.1 nM and 16.2 nM for human and mouse EP4 receptors, respectively. EP4 receptor antagonist 1 can be used for studies about cancer immunotherapy. |
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文献和实验[3H](+)MK801 Radioligand Binding Assay at the N‐Methyl‐D‐Aspartate Receptor
. Bonhaus, D.W. and McNamara, J.O. 1998. N‐methyl‐D‐aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: Kinetic analysis. Mol. Pharmacol. 34:250‐255
Overview of Receptor Allosterism
Figure 1.21.2 Effect of: (A ) negative allosteric modulator, (B ) positive allosteric modulator, or (C ) a competitive antagonist on orthosteric ligand‐receptor occupancy (ρA ). For all the simulations, p K
[D-Arg6 , D-Trp7,9 , Nme Phe8 ]-substance P (6-11) (antagonist G) is a novel class of anti-cancer agent that inhibits small cell lung cancer (SCLC) cell growth in vitro and in vivo and is entering Phase II clinical investigation
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