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- 规格:
2mg/10mg
| 规格: | 2mg | 产品价格: | ¥380.0 |
|---|---|---|---|
| 规格: | 10mg | 产品价格: | ¥1280.0 |
| 产品编号 | D51239 |
| 英文名称 | YM 90709 |
| 中文别名 | IL-5抑制剂 |
| 性状 | Lyophilized |
| 理论分子量 | 359.42 |
| 保存条件 | Store in dry, dark place for one year. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells. |
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YM 90709(D51239)-2mg/10mg
¥380 - 1280






