- ￥2800
- Proteintech
- CL594-67288
- 2025年10月13日
- IF-P
- Mouse
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
None
- 亚型：
IgG1
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite®594 Fluorescent Dye
- 适应物种：
human, mouse
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Mouse
- 应用范围：
IF-P
- 靶点：
Collagen Type I
- 抗体英文名：
CoraLite®594-conjugated Collagen Type I Monoclonal antibody
- 抗体名：
CoraLite®594-conjugated Collagen Type I Monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF-P detected in | human colon cancer tissue, human breast cancer tissue, mouse skin tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL594-67288 targets Collagen Type I in IF-P applications and shows reactivity with human, mouse samples.
| 经测试应用 | IF-P |
| 文献引用应用 | IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | collagen, type I, alpha 1 |
| 别名 | COL1A1, col1, COL I, Alpha-1 type I collagen, Alpha 1 type I collagen |
| 计算分子量 | 139 kDa |
| 观测分子量 | 120-130 kDa |
| GenBank蛋白编号 | NM_000088 |
| 基因名称 | COL1A1 |
| Gene ID (NCBI) | 1277 |
| RRID | AB_2920107 |
| 偶联类型 | CoraLite®594 Fluorescent Dye |
| 最大激发/发射波长 | 588 nm / 604 nm |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P02452 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. This antibody raised against a synthesized peptide corresponding to 1206-1218 aa of human pro-alpha 1 chain of type I collagen recognize collagen alpha-1(I) chain.
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文献和实验| Species | Application | Title |
|---|---|---|
| human | IF | Int J Biol Sci Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinomaAuthors - Jingwei Cai |
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