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- Bioss
- bs-6138R-PE
- 2025年10月15日
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100ul
| 产品编号 | bs-6138R-PE |
| 英文名称 | EID1 Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的乙酰基转移酶EID1抗体 |
| 英文别名 | 21 kDa pRb associated protein; C15orf3; CBP; Chromosome 15 open reading frame 3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI 1; CRI1; E1A like inhibitor of differentiation; EID 1; EP300 interacting inhibitor of differentiation 1; NB4 apoptosis related protein; PNAS 22; PNAS22; PTD014; Rb and p300 binding protein EID 1; Rb and p300 binding protein EID1; RBP21; Retinoblastoma protein associated protein; EID1_HUMAN. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human EID1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors > Rb family Cell Biology > Apoptosis > Intracellular > Associated Proteins Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HAT Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Signal Transduction > Second Messenger > Nucleotide Messenger > cAMP |
| 亚基 | Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27. |
| 亚细胞定位 | Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm. |
| 组织特异性 | Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines. |
| 翻译后修饰 | Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit. |
| 功能 | Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | EID1 ia an acetyltransferase enzyme. It acetylates histones, giving a specific tag for transcriptional activation. EID1 also acetylates non histone proteins, like NCOA3 coactivator. It Mediates cAMP gene regulation by binding specifically to phosphorylated CREB protein and as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP responsive genes. |
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EID1 Rabbit pAb, PE conjugated(bs-6138R-PE)-100ul
￥2980
