- ￥2980
- Bioss
- bs-13344R-Cy5.5
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
Sarcomeric Alpha Actinin Rabbit pAb, BF594 conjugated(bs-10367R-BF594)-100ul
￥2980
phospho-Caspase-9 (Ser196) Rabbit pAb, BF647 conjugated(bs-5241R-BF647)-100ul
￥2980
AP2 gamma Rabbit pAb, BF647 conjugated(bs-6694R-BF647)-100ul
￥2980GRO Alpha Rabbit pAb, Cy5 conjugated(bs-10234R-Cy5)-100ul
￥2980PWWP2 Rabbit pAb, HRP conjugated(bs-21113R-HRP)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-13344R-Cy5.5 |
| 英文名称 | GGA2 Rabbit pAb, Cy5.5 conjugated |
| 中文名称 | Cy5.5标记的γ-衔接蛋白相关蛋白2抗体 |
| 英文别名 | 1200007E24Rik; ADP ribosylation factor binding protein 2; ADP ribosylation factor binding protein GGA 2; ADP ribosylation factor binding protein GGA2; ADP-ribosylation factor-binding protein GGA2; ARF-binding protein 2; FLJ20966; gamma adaptin related protein 2; gamma ear-containing; gamma-adaptin-related protein 2; GGA 2; Gga2; GGA2_HUMAN; Golgi associated gamma adaptin ear containing ARF binding protein 2; Golgi localized gamma ear containing ARF binding protein 2; Golgi-localized; KIAA1080; Vear; VHS domain and ear domain containing protein; VHS domain and ear domain of gamma adaptin; VHS domain and ear domain of gamma-adaptin. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GGA2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚基 | Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2. |
| 亚细胞定位 | Golgi apparatus; trans-Golgi network membrane. Endosome membrane. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Ubiquitinated. |
| 相似性 | Belongs to the GGA protein family. _x000D_ Contains 1 GAE domain. _x000D_ Contains 1 GAT domain. _x000D_ Contains 1 VHS domain. |
| 功能 | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | A family of proteins, the GGAs (Golgi-localized, g-adaptin ear-containing, ARF-binding proteins) sequences that showed significant homology to the carboxy-terminal 'ear' domain of g-adaptin. Members of the GGA family (GGA1,GGA2 (also known as VEAR or VHS domain and ear domain of g-adaptin) and GGA3) are ubiquitous coat proteins that facilitate the trafficking of proteins between the trans-Golgi network and the lysosome. However, unlike g-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membranes. GGA2 shares 45% amino acid sequence identity with GGA1 and 35% with GGA3. In addition to being involved in heterotypic vesicle/suborganelle interactions associated with the Golgi complex, GGA2 may have a tissue-specific function and is highly expressed in kidney, muscle and heart. Furthermore, the VHS domain of GGA2 binds to the acidic cluster-di-leucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR) and this is important for lysosomal enzyme targeting. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
GGA2 Rabbit pAb, Cy5.5 conjugated(bs-13344R-Cy5.5)-100ul
￥2980
