- ￥2980
- Bioss
- bs-7515R-BF750
- 2025年09月30日
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100ul
| 产品编号 | bs-7515R-BF750 |
| 英文名称 | KLHL20 Rabbit pAb, BF750 conjugated |
| 中文名称 | BF750标记的Kelch样蛋白20抗体 |
| 英文别名 | Kelch like ECT2 interacting protein; Kelch like protein 20; Kelch like protein X; Kelch motif containing protein; Kelch-like ECT2-interacting protein; Kelch-like protein 20; Kelch-like protein X; KHLHX; KLEIP; KLH20_HUMAN; KLHL20; KLHLX; RP3-383J4.3. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human KLHL20 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Growth Factors > VEGF > VEGF Cardiovascular > Hypoxia > Hypoxia-Regulated Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with DAPK1. Interacts with F-actin. Interacts with IFN-gamma (IFNG). |
| 亚细胞定位 | Cytoplasm, perinuclear region. Nucleus. Note=Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination. |
| 相似性 | Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. |
| 功能 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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KLHL20 Rabbit pAb, BF750 conjugated(bs-7515R-BF750)-100ul
￥2980
