- ￥2980
- Bioss
- bs-13090R-PacificBlue
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
phospho-MCL1 (Ser159) Rabbit pAb, HRP conjugated(bs-18726R-HRP)-100ul
￥2980
PGC Rabbit pAb, BF488 conjugated(bs-1551R-BF488)-100ul
￥2980IRS-2 Rabbit pAb, APC-Cy7 conjugated(bs-20749R-APC-Cy7)-100ul
￥2980
SAR1A Rabbit pAb, BF680 conjugated(bs-19391R-BF680)-100ul
￥2980
phospho-JNK1/2/3(T183+T183+T221) Recombinant Rabbit mAb, AP conjugated(bsm-52462R-AP)-100ul
￥3200
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-13090R-PacificBlue |
| 英文名称 | phospho-HER2 (Tyr1221) Rabbit pAb, Pacific Blue conjugated |
| 中文名称 | Pacific Blue标记的磷酸化HER2受体抗体 |
| 英文别名 | ErbB 2(phospho Y1221); p-ErbB 2(phospho Y1221); HER2(phospho-Tyr1221); ErbB2; CerbB2; c erb B2; C erbB 2; C-erbB2; CD340; CD340 antigen; Cerb B2/neu protein; Erb B2; erbb2; HER 2; HER 2/neu; Her2/neu; Herstatin; MLN 19; MLN19; NEU; NEU Proto Oncogene; Neuro Glioblastoma Derived Oncogene Homolog; Neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185 ErbB2; p185erbB2; Receptor Protein Tyrosine Kinase ErbB2 Precursor; Receptor tyrosine protein kinase erbB 2; TKR1; ERBB2_HUMAN. |
| 产品应用 | ICC/IF=1:50-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1221 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Growth factors > EGF Cancer > Tumor biomarkers > Oncoproteins Cancer > Tumor immunology > Tumor-associated antigens Signal Transduction > Growth Factors/Hormones > EGF Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Heterodimer with each of ,the other ERBB receptors. The constitutively activated oncogenic variant forms a homodimer. Interacts with PRKCABP and PLXNB1. It is a type I membrane protein. Ligand-binding increases phosphorylation on tyrosine residues Belongs to the Tyr protein kinase family. EGF receptor subfamily. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Isoform 2: Cytoplasm. Nucleus. Isoform 3: Cytoplasm. Nucleus. |
| 组织特异性 | Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
| 翻译后修饰 | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling via SEMA4C promotes phosphorylation at Tyr-1248. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain. |
| 功能 | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization._x000D_
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
phospho-HER2 (Tyr1221) Rabbit pAb, Pacific Blue conjugated(bs-13090R-PacificBlue)-100ul
￥2980
