- ￥2980
- Bioss
- bs-18995R-Cy3
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
IL13 Rabbit pAb, APC-Cy7 conjugated(bs-0560R-APC-Cy7)-100ul
￥2980IGFBP3 Rabbit pAb, HRP conjugated(bs-43124R-HRP)-100ul
￥2980
DRD1 Rabbit pAb, BF750 conjugated(bs-1007R-BF750)-100ul
￥2980KIF3A Rabbit pAb, APC-Cy7 conjugated(bs-21397R-APC-Cy7)-100ul
￥2980
SH3BP1 Rabbit pAb, APC-Cy5.5 conjugated(bs-19748R-APC-Cy5.5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-18995R-Cy3 |
| 英文名称 | Naca Rabbit pAb, Cy3 conjugated |
| 中文名称 | Cy3标记的初生多肽相关复合物亚单位α，肌肉特异型蛋白抗体 |
| 英文别名 | NACAM_HUMAN; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; alpha-NAC, muscle-specific form; skNAC; skNAC; Gm1878; AL022831; AL024382; mKIAA0363. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Alpha-NAC, muscle-specific form |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts (via PXLXP motif) with the muscle-restricted histone methyltransferase SMYD1 (via MYND-type zinc finger). |
| 亚细胞定位 | Cytoplasm. Nucleus. Predominantly cytoplasmic. Also found in nucleus. |
| 组织特异性 | Ubiquitously expressed. |
| 翻译后修饰 | Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the NAC-alpha family. _x000D_ Contains 1 NAC-A/B (NAC-alpha/beta) domain. _x000D_ Contains 1 UBA domain. |
| 功能 | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Naca Rabbit pAb, Cy3 conjugated(bs-18995R-Cy3)-100ul
￥2980
