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- Bioss
- bs-7852R-PacificBlue
- 2025年09月30日
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100ul
| 产品编号 | bs-7852R-PacificBlue |
| 英文名称 | ZWINT Rabbit pAb, Pacific Blue conjugated |
| 中文名称 | Pacific Blue标记的着丝粒ZW10相互作用蛋白1抗体 |
| 英文别名 | HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ZWINT |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Cell Division > Spindle Epigenetics and Nuclear Signaling > Cell cycle > Chromosome Structure > Centromere Epigenetics and Nuclear Signaling > Chromosome Structure > Centromeres |
| 亚基 | Interacts with ZW10 and MIS12. Interacts with the NDC80subunit of the NDC80 complex specifically during mitosis. Alsointeracts with CASC5, CETN3, DSN1 and PMF1. |
| 亚细胞定位 | Nucleus. Chromosome, centromere,kinetochore. Note=Localizes to kinetochores from late prophase toanaphase._x000D_ |
| 功能 | Part of the MIS12 complex, which is required forkinetochore formation and spindle checkpoint activity. Required totarget ZW10 to the kinetochore at prometaphase._x000D_ |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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ZWINT Rabbit pAb, Pacific Blue conjugated(bs-7852R-PacificBlue)-100ul
￥2980
