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- bs-6685R-APC-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-6685R-APC-Cy5.5 |
| 英文名称 | SCN10A/Nav1.8 Rabbit pAb, APC-Cy5.5 conjugated |
| 中文名称 | APC-Cy5.5标记的钠通道蛋白10α抗体 |
| 英文别名 | mPN3; Peripheral nerve sodium channel 3; Pn3(gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns(gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.8; NAV1.8. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SCN10A/NAV1.8 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Sodium Channels Neuroscience > Sensory System > Somatosensory system > Nociception |
| 亚基 | The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10. |
| 组织特异性 | Expressed in the dorsal root ganglia and sciatic nerve. |
| 翻译后修饰 | Ubiquitinated by NEDD4L; which promotes its endocytosis. |
| 相似性 | Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Contains 1 IQ domain. |
| 功能 | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a Tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a Tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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SCN10A/Nav1.8 Rabbit pAb, APC-Cy5.5 conjugated(bs-6685R-APC-Cy5.5)-100ul
￥2980
