TYMS Rabbit pAb, BF555 conjugated(bs-8537R-BF555)-100ul产品图

TYMS Rabbit pAb, BF555 conjuga

ted(bs-8537R-BF555)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-8537R-BF555
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格:

      100ul

    产品编号bs-8537R-BF555
    英文名称TYMS Rabbit pAb, BF555 conjugated
    中文名称BF555标记的胸苷酸合成酶抗体
    英文别名Thymidylate synthase; EC 2.1.1.45; HsT422; MGC88736; TS; TSase; OK/SW-cl.29; TYSY_HUMAN.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TYMS
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Purine and pyrimidine synthesis

    亚基Homodimer.
    亚细胞定位Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane._x000D_
    相似性Belongs to the thymidylate synthase family.
    功能Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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