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- Bioss
- bs-0096R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-0096R-APC |
| 英文名称 | AAT Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的α-1抗胰蛋白酶抗体 |
| 英文别名 | A1AT_HUMAN; alpha-1-antitrypsin; SERPINA1; alpha-1 protease inhibitor; alpha-1-antiproteinase; Serpin A1; PI; PRO0684; PRO2209; serpin family A member 1; A1A; PI1; A1AT; nNIF; PRO2275; alpha1AT; |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human AAT |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cardiovascular > Blood > Serum Proteins Metabolism > Pathways and Processes > Metabolism processes > Hypoxia |
| 亚细胞定位 | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix. |
| 组织特异性 | Plasma. |
| 翻译后修饰 | N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant._x000D_
Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418. |
| 相似性 | Belongs to the serpin family. |
| 功能 | Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin._x000D_
Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Alpha-1-antitrypsin is a protease inhibitor, deficiency of which is associated with emphysema and liver disease. The protein is encoded by a gene (PI) located on the distal long arm of chromosome 14. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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AAT Rabbit pAb, APC conjugated(bs-0096R-APC)-100ul
￥2980
