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- bs-0094R-PE
- 2025年09月30日
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100ul
| 产品编号 | bs-0094R-PE |
| 英文名称 | AACT Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的α-1抗胰糜蛋白酶抗体 |
| 英文别名 | AACT_HUMAN; SERPINA3; alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; GIG24; GIG25; serpin family A member 3; |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human AACT |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Serum Proteins Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Other proteases Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Proteases |
| 亚基 | Interacts with DNAJC1. |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. |
| 相似性 | Belongs to the serpin family. |
| 功能 | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Alpha 1-Antichymotrypsin, a member of the serine proteinase inhibitor (serpin) family, inhibits neutrophil proteinase cathepsin G and mast cell chymases, and protects the lower respiratory tract from damage by proteolytic enzymes. It contains a reactive centre loop, which interacts with cognate proteinases, resulting in loop cleavage and a major conformational change. Recently, alpha 1-antichymotrypsin has been identified as a major constituent of the neurofibrillary plaques associated with Alzheimers disease, and in vitro studies have shown that it enhances the rate of amyloid-fibril formation. These observations and recent genetic evidence suggest that alpha 1-antichymotrypsin is important in the pathogenesis of Alzheimers disease. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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AACT Rabbit pAb, PE conjugated(bs-0094R-PE)-100ul
￥2980
