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- bs-10367R-PE
- 2025年09月30日
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100ul
| 产品编号 | bs-10367R-PE |
| 英文名称 | Sarcomeric Alpha Actinin Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的α横纹肌辅肌动蛋白/α-SCA抗体 |
| 英文别名 | Actin binding protein; Actinin alpha 2; ACTN 2; ACTN2; ACTN2_HUMAN; alpha actinin 2; alpha actinin skeletal muscle; alpha actinin skeletal muscle isoform 2; alpha-actinin skeletal muscle isoform 2; alpha-actinin-2; CMD1AA; F actin cross linking protein; F-actin cross-linking protein; alpha-SCA; sm Actinin-alpha. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Sarcomeric Alpha Actinin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Cardiac arrhythmias Cardiovascular > Heart > Contractility > Contractile Proteins > Actins Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. |
| 亚细胞定位 | Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. |
| 组织特异性 | Expressed in both skeletal and cardiac muscle. |
| 翻译后修饰 | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| 相似性 | Belongs to the alpha-actinin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains 4 spectrin repeats. |
| 功能 | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Sarcomeric Alpha Actinin Rabbit pAb, PE conjugated(bs-10367R-PE)-100ul
￥2980
