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- bs-12998R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-12998R-APC |
| 英文名称 | DGAT2 Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的甘油二酯酰基转移酶2抗体 |
| 英文别名 | DGAT2_HUMAN; Diacylglycerol O acyltransferase like protein 2; Diacylglycerol O-acyltransferase 2; Diacylglycerol O-acyltransferase homolog 2(mouse); Diacylglycerol O-acyltransferase homolog 2; Diacylglycerol O-acyltransferase-like protein 2 isoform 1; Diglyceride acyltransferase 2; DKFZp686A15125; GS1999full; HMFN1045. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DGAT2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Signal Transduction > Metabolism > Lipid metabolism Tags & Cell Markers > Subcellular Markers > Organelles > ER |
| 亚基 | Forms multimeric complexes consisting of several DGAT2 subunits (By similarity). |
| 亚细胞定位 | Endoplasmic reticulum membrane. |
| 组织特异性 | Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. |
| 相似性 | Belongs to the diacylglycerol acyltransferase family. |
| 功能 | Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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DGAT2 Rabbit pAb, APC conjugated(bs-12998R-APC)-100ul
￥2980
