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- Bioss
- bs-5842R-PE-Cy5
- 2025年09月30日
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100ul
| 产品编号 | bs-5842R-PE-Cy5 |
| 英文名称 | MIIP Rabbit pAb, PE-Cy5 conjugated |
| 中文名称 | PE-Cy5标记的IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 |
| 英文别名 | FLJ12438; FLJ38609; IGFBP 2 binding protein; IGFBP2 binding protein; IIP45; Invasion inhibitory protein 45; Migration and invasion inhibitory protein; RP5 1077B9.4. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MIIP |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Cell adhesion Neuroscience > Cell Adhesion Proteins > Cytoskeletal Proteins > Regulation Neuroscience > Cell Adhesion Proteins > Membrane Proteins |
| 亚基 | Interacts with IGFBP2. |
| 组织特异性 | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. |
| 翻译后修饰 | Isoform 2 is degraded by the ubiquitin-proteasome pathway. |
| 功能 | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposing effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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MIIP Rabbit pAb, PE-Cy5 conjugated(bs-5842R-PE-Cy5)-100ul
￥2980
