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- bs-2925R-APC-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-2925R-APC-Cy7 |
| 英文名称 | Klotho Rabbit pAb, APC-Cy7 conjugated |
| 中文名称 | APC-Cy7标记的Klotho多肽蛋白抗体 |
| 英文别名 | KL antibody KLOT_HUMAN; Klotho peptide. |
| 中文别名 | 克老素 |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Klotho |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Post embryonic development > Aging Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism Signal Transduction > Metabolism > Energy Metabolism |
| 亚基 | Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. |
| 亚细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. Isoform 2: Secreted. Klotho peptide: Secreted. |
| 组织特异性 | Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.hepatocellular carcinomas, and in chronic renal failure kidney. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. |
| 功能 | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Klotho Rabbit pAb, APC-Cy7 conjugated(bs-2925R-APC-Cy7)-100ul
￥2980
