ASB2 Rabbit pAb, APC-Cy5.5 conjugated(bs-2835R-APC-Cy5.5)-100ul

ASB2 Rabbit pAb, APC-Cy5.5 con

jugated(bs-2835R-APC-Cy5.5)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-2835R-APC-Cy5.5
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-2835R-APC-Cy5.5
    英文名称ASB2 Rabbit pAb, APC-Cy5.5 conjugated
    中文名称APC-Cy5.5标记的含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体
    英文别名Ankyrin repeat and SOCS box 2 containing protein; Ankyrin repeat and SOCS box containing 2; Ankyrin repeat and SOCS box containing protein 2; Ankyrin repeat containing protein ASB2.ASB2_HUMAN
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ASB2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Cell Cycle > Cell Cycle Inhibitors

    Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors

    Epigenetics and Nuclear Signaling > Cell cycle > Ubiquitin ligases

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families

    亚基Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 and TCEB2) and ASB2
    相似性Contains 12 ANK repeats
    Contains 1 SOCS box domain. _x000D_
    功能Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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