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- Bioss
- bs-2835R-APC-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-2835R-APC-Cy7 |
| 英文名称 | ASB2 Rabbit pAb, APC-Cy7 conjugated |
| 中文名称 | APC-Cy7标记的含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体 |
| 英文别名 | Ankyrin repeat and SOCS box 2 containing protein; Ankyrin repeat and SOCS box containing 2; Ankyrin repeat and SOCS box containing protein 2; Ankyrin repeat containing protein ASB2.ASB2_HUMAN |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ASB2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Cell cycle > Ubiquitin ligases Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families |
| 亚基 | Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 and TCEB2) and ASB2 |
| 相似性 | Contains 12 ANK repeats Contains 1 SOCS box domain. _x000D_ |
| 功能 | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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ASB2 Rabbit pAb, APC-Cy7 conjugated(bs-2835R-APC-Cy7)-100ul
￥2980
