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- bs-14522R-PerCP-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-14522R-PerCP-Cy7 |
| 英文名称 | EGR4 Rabbit pAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的早期生长反应蛋白4抗体 |
| 英文别名 | AT133; EGR4_HUMAN; Early growth response protein 4; Nerve growth factor induced clone C; NGFI C; NGFIC; PAT133. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human EGR4 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚细胞定位 | Nuclear |
| 相似性 | Belongs to the EGR C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers._x000D_ |
| 功能 | EGR4(Early Growth Response protein 4) is a zinc-finger transcription factor that activates the transcription of genes whose products are required for mitogenesis and differentiation. EGR4 is closely related to nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3. These four early response (immediate early) proteins all contain very similar zinc-finger DNA binding domains and five highly homologous subdomains. EGR4 functionally cooperate with NFAT proteins and induce expression of IL2 and TNFalpha. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Egr-1, Egr-2, Egr-3 and Egr-4 are nuclear transcription factors belonging to the Egr C2H2-type zinc-finger protein family and containing three C2H2-type zinc fingers. As immediate early proteins, Egr transcription factors are rapidly induced by diverse extracellular stimuli. They are subject to tight differential control through diverse mechanisms at several levels of regulation: transcriptional; translational and posttranslational (including glycosylation, phosphorylation and redox) mechanisms; and protein-protein interaction. Egr-1 binds to the DNA sequence 5'-CGCCCCCGC-3' (Egr-site), thereby activating transcription of target genes whose products are required for mitogenisis and differentiation. Egr-2 binds specific DNA sites located in the promoter region of HoxA4. Egr-2 defects cause congenital hypomyelination neuropathy (also designated Charcot-Marie-Tooth disease) and Dejerine-Sottas neuropathology (also designated hereditary motor and sensory neuropathy III). Egr-3 is involved in muscle spindle development and is expressed in T cells 20 minutes following activation. Egr-4 binds to the Egr consensus motif GCGTGGGCG, functions as a transcriptional repressor, and displays autoregulatory activities, downregulating its own gene promoter in a dose dependent manner. |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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EGR4 Rabbit pAb, PerCP-Cy7 conjugated(bs-14522R-PerCP-Cy7)-100ul
￥2980
