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- bs-14519R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-14519R-APC |
| 英文名称 | phospho-eIF2B epsilon (Ser539) Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的磷酸化eIF2B蛋白抗体 |
| 英文别名 | eIF2B epsilon(phospho S539); CACH; CLE; EI2BE_HUMAN; EIF 2B; eIF 2B GDP GTP exchange factor; eIF 2B GDP GTP exchange factor subunit epsilon; eIF-2B GDP-GTP exchange factor subunit epsilon; EIF2B; EIF2B5; EIF2BE; EIF2Bepsilon; Eukaryotic Translation Initiation Factor 2 beta Epsilon; Eukaryotic Translation Initiation Factor 2 beta Epsilon; Eukaryotic translation initiation factor 2B subunit 5 epsilon 82kDa; Eukaryotic translation initiation factor 2B subunit 5 epsilon; LVWM; Translation initiation factor eIF 2B subunit epsilon; Translation initiation factor eIF-2B subunit epsilon. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human EFHC1 around the phosphorylation site of Ser539 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Regulation Epigenetics and Nuclear Signaling > RNAi > Eukaryotic Initiation factors (eIF's) |
| 亚基 | Complex of five different subunits; alpha, beta, gamma, delta and epsilon. Interacts with RGS2. |
| 组织特异性 | Widely expressed. Not detected in lymphocytes. |
| 翻译后修饰 | Phosphorylated at Ser-544 by DYRK2; this is required for subsequent phosphorylation by GSK3B (By similarity). Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function. Polyubiquitinated, probably by NEDD4 (By similarity)._x000D_ |
| 相似性 | Belongs to the eIF-2B gamma/epsilon subunits family. _x000D_ Contains 1 W2 domain. |
| 功能 | Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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phospho-eIF2B epsilon (Ser539) Rabbit pAb, APC conjugated(bs-14519R-APC)-100ul
￥2980
