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- Bioss
- bs-0991R-BF405
- 2025年09月30日
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100ul
| 产品编号 | bs-0991R-BF405 |
| 英文名称 | HPV18 E6 protein Rabbit pAb, BF405 conjugated |
| 中文名称 | BF405标记的人类乳头状瘤病毒18 E6抗体 |
| 英文别名 | E6; Human Papilloma Virus; Human papillomavirus type 18 E6; Human papillomavirus type 18(E6); Human papillomavirus type 18 E6; Human papillomavirus type 18 E6 protein; Protein E6; HPV18 E6 protein; VE6_HPV18. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from HPV18 E6 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Forms a complex with E6-AP ubiquitin-protein ligase which interacts with human P53. Binds to human FBLN1, MAGI3 and MPDZ. |
| 亚细胞定位 | Host nucleus matrix (By similarity). |
| 相似性 | Belongs to the papillomaviridae E6 protein family. |
| 功能 | Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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HPV18 E6 protein Rabbit pAb, BF405 conjugated(bs-0991R-BF405)-100ul
￥2980
