TUT4 | ZCH11 Rabbit pAb, BF488 conj.(bs-18565R-BF488)-100ul产品图

TUT4 | ZCH11 Rabbit pAb, BF488

conj.(bs-18565R-BF488)-100ul
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  • bs-18565R-BF488
  • 2026年10月17日
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    北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-18565R-BF488
    英文名称ZCH11 Rabbit pAb, BF488 conjugated
    中文名称BF488标记的ZCH11蛋白抗体
    英文别名DKFZp779C1943; EC 2.7.7.52; FLJ42878; KIAA0191; PAP associated domain containing 3; PAPD3; Terminal uridylyltransferase 4; TUT4; TUT4_HUMAN; TUTase 4; ZCCHC 11; ZCCHC11; Zinc finger CCHC domain containing 11; Zinc finger CCHC domain containing protein 11; Zinc finger CCHC domain-containing protein 11.
    产品应用ICC/IF=1:50-200, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ZCH11
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    亚细胞定位Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.
    翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the DNA polymerase type-B-like family.
    _x000D_ Contains 3 CCHC-type zinc fingers.
    _x000D_ Contains 2 PAP-associated domains.
    功能Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

     

    应用推荐稀释比例
    {ICC/IF}{1:50-200}
    {IF}{1:100-500}

     

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