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- bs-4619R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-4619R-AP |
| 英文名称 | H1N1+H3N2 nucleocapsid protein Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的A型流感病毒核衣壳蛋白抗体 |
| 英文别名 | Influenza A virus(H1N1/H5N1/H3N2); H1N1 Influenza A virus Nucleocapsid protein; nucleocapsid protein [Influenza A virus(A/swine/MB/54/2009(H1N1))]. |
| 产品应用 | ELISA=1:500-5000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from H1N1/H5N1/H3N2 nucleocapsid protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Organism > Virus > RNA Virus > single stranded RNA negative strand virus > Influenza Microbiology > Protein > Viral Protein |
| 亚基 | Homotetramer; composed of two disulfide-linked dimmers held together by non-covalent interactions. May interact with matrix protein 1. |
| 亚细胞定位 | Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion). |
| 相似性 | Belongs to the influenza viruses matrix protein M2 family. |
| 功能 | Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species jumping ability. |
| 应用 | 推荐稀释比例 |
| {ELISA} | {1:500-5000} |
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H1N1+H3N2 nucleocapsid protein Rabbit pAb, AP conjugated(bs-4619R-AP)-100ul
￥2980
