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- bs-15536R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-15536R-BF350 |
| 英文名称 | ICK Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的丝氨酸/苏氨酸蛋白激酶ICK抗体 |
| 英文别名 | 2210420N10Rik; AI848300; ECO; ICK_HUMAN; Heart serine threonine protein kinase; hICK; Intestinal cell(MAK like) kinase; Intestinal cell kinase; KIAA0936; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MAK related kinase; MGC46090; mICK; MRK; OTTMUSP00000041856; OTTMUSP00000041857; Serine/threonine-protein kinase ICK; Serine/threonine protein kinase ICK. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ICK |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Nucleus. Cytoplasm, cytosol. Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168). |
| 组织特异性 | Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. |
| 翻译后修饰 | Autophosphorylated on serine and threonine residues. May play a role in enzyme activation. |
| 相似性 | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
| 功能 | May play a key role in the development of multiple organ systems and particularly in cardiac development. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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ICK Rabbit pAb, BF350 conjugated(bs-15536R-BF350)-100ul
￥2980
