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- bs-13699R-APC
- 2025年09月30日
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100ul
| 产品编号 | bs-13699R-APC |
| 英文名称 | SAM68 Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的SRC有丝分裂相关蛋白68抗体 |
| 英文别名 | FLJ34027; GAP associated tyrosine phosphoprotein p62; GAP-associated tyrosine phosphoprotein p62; KH domain containing RNA binding signal transduction associated 1; KH domain-containing; KHDR1_HUMAN; KHDRBS1; p21 Ras GTPase activating protein associated p62; p21 Ras GTPase-activating protein-associated p62; p62; p68; RNA-binding; Sam68; signal transduction-associated protein 1; Src associated in mitosis 68 kDa protein; Src-associated in mitosis 68 kDa protein. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SAM68 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Adapters > Transmembrane |
| 亚细胞定位 | Nucleus. Membrane. |
| 组织特异性 | Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver. |
| 翻译后修饰 | Tyrosine phosphorylated by several non-receptor tyrosine kinases, for example LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. _x000D_ Acetylated. Positively correlates with ability to bind RNA. _x000D_ Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30._x000D_ Arg-291, Arg-331 and Arg-346 are found to be also dimethylated, probably to asymmetric dimethylarginine. |
| 相似性 | Belongs to the KHDRBS family. _x000D_ Contains 1 KH domain. |
| 功能 | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export._x000D_ Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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SAM68 Rabbit pAb, APC conjugated(bs-13699R-APC)-100ul
￥2980
