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- bs-7350R-PerCP
- 2025年09月30日
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100ul
| 产品编号 | bs-7350R-PerCP |
| 英文名称 | SIRT2 Rabbit pAb, PerCP conjugated |
| 中文名称 | PerCP标记的沉默调节相关蛋白2抗体 |
| 英文别名 | FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; Sirtuin(silent mating type information regulation 2 homolog) 2(S.cerevisiae); Sirtuin 2; Sirtuin type 2; Sirtuin2. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SIRT2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class I Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > Tubulin |
| 亚细胞定位 | Cytoplasm, cytoskeleton. Colocalizes with microtubules. |
| 组织特异性 | Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network._x000D_ |
| 翻译后修饰 | Phosphorylated at the G2/M transition of the cell cycle. |
| 相似性 | Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain. |
| 功能 | NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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SIRT2 Rabbit pAb, PerCP conjugated(bs-7350R-PerCP)-100ul
￥2980
