- ￥2980
- Bioss
- bs-5162R-RBITC
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
SIRT1 Rabbit pAb, PerCP-Cy5.5 conjugated(bs-0921R-PerCP-Cy5.5)-100ul
￥2980
TREML2 Rabbit pAb, Biotin conjugated(bs-2737R-Bio)-100ul
￥2980Collagen II Rabbit pAb, PE conjugated(bs-10589R-PE)-100ul
￥2980
phospho-Met (Tyr1234 + Tyr1235) Rabbit pAb, RBITC conjugated(bs-3272R-RBITC)-100ul
￥2980phospho-P53 (Ser33) Rabbit pAb, BF405 conjugated(bs-3705R-BF405)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-5162R-RBITC |
| 英文名称 | AADACL1 Rabbit pAb, RBITC conjugated |
| 中文名称 | RBITC标记的中性胆固醇酯水解酶1抗体 |
| 英文别名 | Arylacetamide deacetylase like 1; Arylacetamide deacetylase-like 1; Kiaa1363; NCEH; Nceh1; NCEH1_HUMAN; Neutral cholesterol ester hydrolase 1; Neutral cholesterol ester hydrolase. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human AADACL1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers > Enzymes Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > Lipid Signaling |
| 亚细胞定位 | Membrane; Single-pass type II membraneprotein (Probable). Microsome |
| 组织特异性 | Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Belongs to the 'GDXG' lipolytic enzyme family. |
| 功能 | Hydrolyzes 2-acetyl monoalkylglycerol ether, thepenultimate precursor of the pathway for de novo synthesis ofplatelet-activating factor. May be responsible for cholesterolester hydrolysis in macrophages, thereby contributing to thedevelopment of atherosclerosis. Also involved in organdetoxification by hydrolyzing exogenous organophosphorus compounds.May contribute to cancer pathogenesis by promoting tumor cellmigration. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
AADACL1 Rabbit pAb, RBITC conjugated(bs-5162R-RBITC)-100ul
￥2980
