- ￥2980
- Bioss
- bs-1209R-BF680
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
Haemophilus influenza Rabbit pAb, HRP conjugated(bs-15403R-HRP)-100ul
￥2980
CDC2L1 Rabbit pAb, BF647 conjugated(bs-5746R-BF647)-100ul
￥2980
GLUT3 Rabbit pAb, BF488 conjugated(bs-1207R-BF488)-100ul
￥2980Phosphor-PPP3CA (Ser469) Rabbit pAb, PerCP conjugated(bs-10343R-PerCP)-100ul
￥2980
WDR26 Rabbit pAb, RBITC conjugated(bs-0932R-RBITC)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-1209R-BF680 |
| 英文名称 | GRK2 Rabbit pAb, BF680 conjugated |
| 中文名称 | BF680标记的G蛋白偶合受体激酶2抗体 |
| 英文别名 | G-protein coupled receptor kinase 2; ADRBK 1; ADRBK1; Adrenergic beta receptor kinase 1; BARK 1; BARK; BARK1; beta adrenergic receptor kinase 1; beta ARK 1; beta ARK1; G Protein Coupled Receptor Kinase 2; G protein dependent receptor kinase 2; FLJ16718; GRK 2; ARBK1_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GRK2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Adrenergic Receptors Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1. |
| 组织特异性 | Expressed in peripheral blood leukocytes. |
| 相似性 | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. _x000D_ Contains 1 AGC-kinase C-terminal domain. _x000D_ Contains 1 PH domain. _x000D_ Contains 1 protein kinase domain. _x000D_ Contains 1 RGS domain. |
| 功能 | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
GRK2 Rabbit pAb, BF680 conjugated(bs-1209R-BF680)-100ul
￥2980
