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- bs-5814R-PerCP-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-5814R-PerCP-Cy5.5 |
| 英文名称 | Prominin 2 Rabbit pAb, PerCP-Cy5.5 conjugated |
| 中文名称 | PerCP-Cy5.5标记的造血干细胞抗原CD133相关蛋白抗体 |
| 英文别名 | hPROML2; PROM 2; PROM2; Prominin like protein 2; Prominin related protein; PROML2; PROM2_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Prominin 2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis Cancer > Invasion/microenvironment > Apoptosis Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Tumor Suppressors |
| 亚基 | Binds cholesterol (By similarity). |
| 亚细胞定位 | Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. |
| 组织特异性 | Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. |
| 翻译后修饰 | Glycosylated (By similarity). |
| 相似性 | Belongs to the prominin family. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30%, but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues.Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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Prominin 2 Rabbit pAb, PerCP-Cy5.5 conjugated(bs-5814R-PerCP-Cy5.5)-100ul
￥2980
