PSMC3 Rabbit pAb, RBITC conjugated(bs-19463R-RBITC)-100ul

PSMC3 Rabbit pAb, RBITC conjug

ated(bs-19463R-RBITC)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-19463R-RBITC
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-19463R-RBITC
    英文名称PSMC3 Rabbit pAb, RBITC conjugated
    中文名称RBITC标记的蛋白酶体26S亚基ATP酶3抗体
    英文别名26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; H‌‌uman immunodeficiency virus tat transactivator binding protein 1; MGC8487; Proteasome(prosome macropain) 26S subunit ATPase 3; Proteasome 26S ATPase subunit 3; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; PRS6A_HUMAN; PSMC 3; PSMC3; Tat binding protein 1; TAT-binding protein 1; TBP-1; TBP1.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PSMC3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Proteasome

    亚细胞定位Cytoplasm. Nucleus.
    翻译后修饰Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
    相似性Belongs to the AAA ATPase family.
    功能The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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