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- Bioss
- bs-10339R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-10339R-AP |
| 英文名称 | Factor I heavy chain Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的补体因子I重链抗体 |
| 英文别名 | Complement factor I heavy chain; Factor I heavy chain; AHUS3; C3b INA; C3b inactivator; C3B/C4B inactivator; C3BINA; CFAI_HUMAN; CFI; Complement component I; Complement control protein factor I; Complement factor I; F1; factor I; FactorI; FI; I factor; IF; KAF; Konglutinogen activating factor; Heavy chain of factor I; OTTHUMP00000219728. |
| 产品应用 | WB=1000-10000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Complement factor I heavy chain |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Complement > Regulatory |
| 亚细胞定位 | Secreted; extracellular space. |
| 组织特异性 | Plasma. |
| 相似性 | Belongs to the peptidase S1 family. _x000D_ Contains 1 Kazal-like domain. _x000D_ Contains 2 LDL-receptor class A domains. _x000D_ Contains 1 peptidase S1 domain. _x000D_ Contains 1 SRCR domain. |
| 功能 | Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively._x000D_ Subcellular Location : Secreted; extracellular space. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage. |
| 应用 | 推荐稀释比例 |
| {WB} | {1000-10000} |
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Factor I heavy chain Rabbit pAb, AP conjugated(bs-10339R-AP)-100ul
￥2980
