Factor I heavy chain Rabbit pAb, IRDye 800CW conjugated(bs-10339R-IRDye800CW)-100ul

Factor I heavy chain Rabbit pA

b, IRDye 800CW conjugated(bs-10339R-IRDye800CW)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-10339R-IRDye800CW
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bs-10339R-IRDye800CW
    英文名称Factor I heavy chain Rabbit pAb, IRDye 800CW conjugated
    中文名称IRDye 800CW标记的补体因子I重链抗体
    英文别名Complement factor I heavy chain; Factor I heavy chain; AHUS3; C3b INA; C3b inactivator; C3B/C4B inactivator; C3BINA; CFAI_HUMAN; CFI; Complement component I; Complement control protein factor I; Complement factor I; F1; factor I; FactorI; FI; I factor; IF; KAF; Konglutinogen activating factor; Heavy chain of factor I; OTTHUMP00000219728.
    产品应用WB=1000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Complement factor I heavy chain
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Immunology > Innate Immunity > Complement > Regulatory

    亚细胞定位Secreted; extracellular space.
    组织特异性Plasma.
    相似性Belongs to the peptidase S1 family.
    _x000D_ Contains 1 Kazal-like domain.
    _x000D_ Contains 2 LDL-receptor class A domains.
    _x000D_ Contains 1 peptidase S1 domain.
    _x000D_ Contains 1 SRCR domain.
    功能Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively._x000D_ Subcellular Location : Secreted; extracellular space.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins; Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.

     

    应用推荐稀释比例
    {WB}{1000-10000}

     

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