phospho-CD130/gp130 (Ser782) Rabbit pAb, BF405 conjugated(bs-10122R-BF405)-100ul

phospho-CD130/gp130 (Ser782) R

abbit pAb, BF405 conjugated(bs-10122R-BF405)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-10122R-BF405
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-10122R-BF405
    英文名称phospho-CD130/gp130 (Ser782) Rabbit pAb, BF405 conjugated
    中文名称BF405标记的磷酸化gp130抗体
    英文别名gp130(phospho S782); gp130(phospho Ser782); p-gp130(Ser782); Interleukin-6 receptor subunit beta; IL-6R-beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; CDw130; Oncostatin-M receptor subunit alpha; CD_antigen; CD130; GP130 RAPS; gp130 transducer chain; GP130-RAPS; IL6 ST; IL6R-beta; IL6ST.IL6R-beta; IL6RB_HUMAN; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthesised phosphopeptide derived from human gp130 around the phosphorylation site of Ser782
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Signal transduction

    Cardiovascular > Atherosclerosis > Apoptosis

    Cardiovascular > Heart > Apoptosis

    Cardiovascular > Heart > Hypertrophy

    Cell Biology > Apoptosis > Intracellular > Associated Proteins

    Immunology > Cell Type Markers > CD > Cytokines

    Signal Transduction > Adapters > Transmembrane

    亚基Interacts with IN‌‌PP5D/SHIP1. Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.
    亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
    组织特异性Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
    翻译后修饰Phosphorylation of Ser-782 down-regulates cell surface expression.
    Heavily N-glycosylated.
    相似性Belongs to the type I cytokine receptor family. Type 2 subfamily._x000D_
    Contains 5 fibronectin type-III domains. _x000D_
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    功能Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料bs-1459P is one synthetic peptide derived from human IL6R beta. CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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