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- bs-15507R-BF680
- 2025年09月30日
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100ul
| 产品编号 | bs-15507R-BF680 |
| 英文名称 | COMT Rabbit pAb, BF680 conjugated |
| 中文名称 | BF680标记的儿茶酚O甲基移位酶抗体 |
| 英文别名 | Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human COMT |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism Metabolism > Types of disease > Cancer Metabolism > Types of disease > Neurodegenerative disease Neuroscience > Neurology process > Neurodegenerative disease > Parkinson's disease Signal Transduction > Metabolism > Drug metabolism |
| 亚细胞定位 | Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side. |
| 组织特异性 | Brain, liver, placenta, lymphocytes and erythrocytes. |
| 翻译后修饰 | The N-terminus is blocked. |
| 相似性 | Belongs to the mammalian catechol-O-methyltransferase family. |
| 功能 | Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-Methyl DOPA and isoproterenol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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COMT Rabbit pAb, BF680 conjugated(bs-15507R-BF680)-100ul
￥2980
