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- Bioss
- bs-6299R-APC-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-6299R-APC-Cy5.5 |
| 英文名称 | DRES17 Rabbit pAb, APC-Cy5.5 conjugated |
| 中文名称 | APC-Cy5.5标记的乳腺癌相关蛋白DRES17抗体 |
| 英文别名 | DRES17; Drosophila-related expressed sequence 17; hprune; HTCD37; Prune homolog; PRUNE like protein; TcD37 homolog; PRUNE_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DRES17 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Cell survival & death Cancer > Tumor biomarkers > Oncoproteins Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized. |
| 亚细胞定位 | Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed. |
| 组织特异性 | Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. |
| 相似性 | Belongs to the PPase class C family. Prune subfamily. |
| 功能 | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | PRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Human prune (h-prune), a phosphoesterase DHH family appertaining protein, physically interacts with nm23-H1, a metastasis suppressor gene. h-prune is involved in cellular motility and metastasis formation. Metastatic breast cancers were found to overexpress h-prune; h-prune was also found to be highly expressed in colorectal and pancreatic cancers. Hence h-prune is considered useful as a marker for tumor aggressiveness. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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DRES17 Rabbit pAb, APC-Cy5.5 conjugated(bs-6299R-APC-Cy5.5)-100ul
￥2980
